Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Clinical type 1 diabetes is preceded by an asymptomatic phase that can be identified by
serum islet autoantibodies. This perspective proposes that there is now sufficient evidence …

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

Environmental factors play an important role in the pathogenesis of type 1 diabetes and can
determine if a genetically susceptible individual develops the disease. Increasing evidence …

Immune biomarkers of type 1 diabetes are many and diverse. Some of these, such as the
autoantibodies, are well established but not discriminative enough to deal with the …

Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells,
leading to insufficient production of insulin and development of hyperglycemia. Serum …

OBJECTIVE To identify circulating proteins influencing type 1 diabetes susceptibility using
Mendelian randomization (MR). RESEARCH DESIGN AND METHODS We used a large …

Summary Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient
availability of biomarkers represents a significant gap in understanding the disease cause …

Aims/hypothesis There is a growing need for markers that could help indicate the decline in
beta cell function and recognise the need and efficacy of intervention in type 1 diabetes …