Risk factors, clinical features and treatment of Behçet's disease uveitis

Z Zhong, G Su, P Yang - Progress in Retinal and Eye Research, 2023 - Elsevier
Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

The immunogenetics of Behçet's disease: A comprehensive review

M Takeuchi, DL Kastner, EF Remmers - Journal of autoimmunity, 2015 - Elsevier
Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …

Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31. 2 and 10q21. 3

S Hou, L Du, B Lei, CP Pang, M Zhang, W Zhuang… - Nature …, 2014 - nature.com
To identify new genetic risk factors for Vogt-Koyanagi-Harada (VKH) syndrome, we
conducted a genome-wide association study of 2,208,258 SNPs in 774 cases and 2,009 …

Genetics of Behçet's disease: lessons learned from genomewide association studies

A Gül - Current opinion in rheumatology, 2014 - journals.lww.com
GWAS data established a major step forward by providing insights into the underlying
mechanisms in Behçet's disease with the discovery of new susceptibility genes. These …

Are neutrophilic dermatoses autoinflammatory disorders?

TK Satoh, M Mellett, E Contassot… - British Journal of …, 2018 - academic.oup.com
Neutrophils constitute essential players in inflammatory responses and are the first line of
defence against harmful stimuli. However, dysregulation of neutrophil homeostasis can …

Biological Treatments in Behçet's Disease: Beyond Anti‐TNF Therapy

F Caso, L Costa, D Rigante… - Mediators of …, 2014 - Wiley Online Library
Behçet's disease (BD) is universally recognized as a multisystemic inflammatory disease of
unknown etiology with chronic course and unpredictable exacerbations: its clinical spectrum …

Genetics of Behcet's disease: functional genetic analysis and estimating disease heritability

L Ortiz-Fernández, AH Sawalha - Frontiers in Medicine, 2021 - frontiersin.org
Behçet's disease is a chronic multisystemic inflammatory disorder characterized by recurrent
oral and genital ulcers. Although its etiology remains unclear, it is thought that both genetic …

Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease

JH Kappen, C Medina-Gomez, PM Hagen, L Stolk… - PloS one, 2015 - journals.plos.org
Introduction The etiology of Behçet's disease (BD) is unknown, but widely considered an
excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent …

Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery

G Leung, C Baggott, C West, C Elboim… - … research and biology, 2014 - liebertpub.com
Background: Lymphedema (LE) is a frequent complication following breast cancer
treatment. While progress is being made in the identification of phenotypic risk factors for the …

HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population

MA Montes-Cano, M Conde-Jaldón… - Arthritis research & …, 2013 - Springer
Introduction According to genome wide association (GWA) studies as well as candidate
gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA) …