With the advancement of technology, drug delivery systems and molecules with more
complex architecture are developed. As a result, the drug absorption and disposition …

The content of this article derives from a Health and Environmental Sciences Institute (HESI)
consortium with a focus to improve cardiac safety during drug development. A detailed …

The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the
potential for delayed ventricular repolarization and is a core safety assay mentioned in …

The ICH E14/S7B Q&As highlighted the need for best practices concerning the design,
execution, analysis, interpretation, and reporting of the in vivo non‐rodent QT assay as a …

Four classes of antibacterial agents that operate by inhibition of the Type II topoisomerases,
DNA gyrase and Topoisomerase IV, have progressed at least through Phase 2 clinical trials …

Introduction Nonclinical evaluation of the cardiovascular effects of novel chemical or
biological entities (NCE, NBEs) is crucial for supporting first-in-human clinical trials. One …

Проведено изучение параметров электрокардиограммы (продолжительность зубцов и
интервалов) у здоровых собак весом от 10 до 20 кг в возрасте от 13 до 36 месяцев в …

Considering the importance of sheep, economically and in research, it is necessary to
explain what normal sheep electrocardiogram values are, and the factors that can cause …

Recently, we have shown how pharmacokinetic-pharmacodynamic (PKPD) modelling can
be used to assess the probability of QT interval prolongation both in dogs and humans. A …

Arrhythmogenic right ventricular cardiomyopathy has high incidence in the boxer dogs. They
may manifest the disease at any age. Dogs can vary from asymptomatic or show clinical …