[HTML][HTML] Antimicrobial resistance in Acinetobacter baumannii: From bench to bedside

MF Lin, CY Lan - World Journal of Clinical Cases: WJCC, 2014 - ncbi.nlm.nih.gov
Acinetobacter baumannii (A. baumannii) is undoubtedly one of the most successful
pathogens in the modern healthcare system. With invasive procedures, antibiotic use and …

Two component regulatory systems and antibiotic resistance in Gram-negative pathogens

AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019 - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations

EJ Yoon, P Courvalin… - Antimicrobial agents and …, 2013 - Am Soc Microbiol
Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-
type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter …

Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii

C Rumbo, E Gato, M López… - Antimicrobial agents …, 2013 - Am Soc Microbiol
We investigated the mechanisms of resistance to carbapenems, aminoglycosides,
glycylcyclines, tetracyclines, and quinolones in 90 multiresistant clinical strains of …

Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital

M Deng, MH Zhu, JJ Li, S Bi, ZK Sheng… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Because of its remarkable ability to acquire antibiotic resistance and to survive in
nosocomial environments, Acinetobacter baumannii has become a significant nosocomial …

MexXY multidrug efflux system of Pseudomonas aeruginosa

Y Morita, J Tomida, Y Kawamura - Frontiers in microbiology, 2012 - frontiersin.org
Anti-pseudomonas aminoglycosides, such as amikacin and tobramycin, are used in the
treatment of Pseudomonas aeruginosa infections. However, their use is linked to the …

Colistin and tigecycline resistance in carbapenemase‐producing Gram‐negative bacteria: emerging resistance mechanisms and detection methods

J Osei Sekyere, U Govinden, LA Bester… - Journal of applied …, 2016 - academic.oup.com
A literature review was undertaken to ascertain the molecular basis for tigecycline and
colistin resistance mechanisms and the experimental basis for the detection and delineation …

The emergence of clinical resistance to tigecycline

Y Sun, Y Cai, X Liu, N Bai, B Liang, R Wang - International journal of …, 2013 - Elsevier
Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-
negative pathogens. However, clinical resistance has emerged recently and has been …

Acinetobacter baumannii: Pathogenesis, virulence factors, novel therapeutic options and mechanisms of resistance to antimicrobial agents with emphasis on …

R Dehbanipour, Z Ghalavand - Journal of Clinical Pharmacy …, 2022 - Wiley Online Library
What is known and objective Acinetobacter baumannii is one of the most important
nosocomial pathogens with the ability to cause infections such as meningitis, pneumonia …

Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M)

S Fiedler, JK Bender, I Klare, S Halbedel… - Journal of …, 2016 - academic.oup.com
Objectives Tigecycline represents one of the last-line therapeutics to combat multidrug-
resistant bacterial pathogens, including VRE and MRSA. The German National Reference …