Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are
heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of …

Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …

Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are
tightly organized immune cell aggregates that are the central structure of tuberculosis …

Background & Aims Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(NAFLD/NASH) is an increasing clinical problem associated with progression to …

Although they are primitive vertebrates, zebrafish (Danio rerio) and medaka (Oryzias latipes)
have surpassed other animals as the most used model organisms based on their many …

The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …

The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal,
viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of …

The success of marker-based approaches for dissecting haematopoiesis in mouse and
human is reliant on the presence of well-defined cell surface markers specific for diverse …