Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

GJ Biessels, F Despa - Nature Reviews Endocrinology, 2018 - nature.com
Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

At the interface of sensory and motor dysfunctions and Alzheimer's disease

MW Albers, GC Gilmore, J Kaye, C Murphy… - Alzheimer's & …, 2015 - Elsevier
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Mouse models of Alzheimer's disease

G Esquerda-Canals, L Montoliu-Gaya… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …

Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies

A Luo, Z Xie, Y Wang, X Wang, S Li, J Yan… - Neuroscience & …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

[HTML][HTML] Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin …

RCL Ng, OY Cheng, M Jian, JSC Kwan… - Molecular …, 2016 - Springer
Background Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus
(T2DM) and these patients have doubled risk of Alzheimer's disease (AD). Increasing …

The GLP‐1/GIP dual‐receptor agonist DA5‐CH inhibits the NF‐κB inflammatory pathway in the MPTP mouse model of Parkinson's disease more effectively than the …

MJ Lv, GF Xue, HF Cheng, PF Meng, X Lian… - Brain and …, 2021 - Wiley Online Library
The GLP‐1 receptor agonist exendin‐4 has recently shown good effects in a phase II clinical
trial in Parkinson's disease (PD) patients. Here, a comparison of the new GLP‐1/GIP dual …

[HTML][HTML] Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients

Y Chang, CK Kim, MK Kim, WK Seo, K Oh - Scientific reports, 2021 - nature.com
Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease.
However, the relationship between insulin resistance and the prognosis of acute ischemic …

The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD

C Li, W Liu, X Li, Z Zhang, H Qi, S Liu, N Yan… - Brain and …, 2020 - Wiley Online Library
Introduction Alzheimer's disease (AD) is the most common progressive neurodegenerative
disease for which there is no cure. Recent studies have shown a close link between type 2 …

Crucial players in Alzheimer's disease and diabetes mellitus: friends or foes?

AM Kubis-Kubiak, A Rorbach-Dolata… - Mechanisms of Ageing …, 2019 - Elsevier
Alzheimer's disease (AD) and diabetes mellitus, especially type 2 (T2DM), are very common
and widespread diseases in contemporary societies, and their incidence is steadily on the …