Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
GJ Biessels, F Despa - Nature Reviews Endocrinology, 2018 - nature.com
Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
At the interface of sensory and motor dysfunctions and Alzheimer's disease
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
Mouse models of Alzheimer's disease
G Esquerda-Canals, L Montoliu-Gaya… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …
40 million people worldwide and it is predicted to exponentially increase in the coming …
Type 2 diabetes mellitus-associated cognitive dysfunction: advances in potential mechanisms and therapies
A Luo, Z Xie, Y Wang, X Wang, S Li, J Yan… - Neuroscience & …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …
personal health and put an enormous burden on the healthcare system, and increasing …
[HTML][HTML] Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin …
RCL Ng, OY Cheng, M Jian, JSC Kwan… - Molecular …, 2016 - Springer
Background Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus
(T2DM) and these patients have doubled risk of Alzheimer's disease (AD). Increasing …
(T2DM) and these patients have doubled risk of Alzheimer's disease (AD). Increasing …
The GLP‐1/GIP dual‐receptor agonist DA5‐CH inhibits the NF‐κB inflammatory pathway in the MPTP mouse model of Parkinson's disease more effectively than the …
MJ Lv, GF Xue, HF Cheng, PF Meng, X Lian… - Brain and …, 2021 - Wiley Online Library
The GLP‐1 receptor agonist exendin‐4 has recently shown good effects in a phase II clinical
trial in Parkinson's disease (PD) patients. Here, a comparison of the new GLP‐1/GIP dual …
trial in Parkinson's disease (PD) patients. Here, a comparison of the new GLP‐1/GIP dual …
[HTML][HTML] Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease.
However, the relationship between insulin resistance and the prognosis of acute ischemic …
However, the relationship between insulin resistance and the prognosis of acute ischemic …
The novel GLP‐1/GIP analogue DA5‐CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD
C Li, W Liu, X Li, Z Zhang, H Qi, S Liu, N Yan… - Brain and …, 2020 - Wiley Online Library
Introduction Alzheimer's disease (AD) is the most common progressive neurodegenerative
disease for which there is no cure. Recent studies have shown a close link between type 2 …
disease for which there is no cure. Recent studies have shown a close link between type 2 …
Crucial players in Alzheimer's disease and diabetes mellitus: friends or foes?
AM Kubis-Kubiak, A Rorbach-Dolata… - Mechanisms of Ageing …, 2019 - Elsevier
Alzheimer's disease (AD) and diabetes mellitus, especially type 2 (T2DM), are very common
and widespread diseases in contemporary societies, and their incidence is steadily on the …
and widespread diseases in contemporary societies, and their incidence is steadily on the …