The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

The synapse has emerged as a critical neuronal structure in the degenerative process of
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …

Alzheimer's disease (AD) is the most common dementia in the elderly. Treatment for AD is
still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is …

The most prevalent form of dementia in the elderly is Alzheimer's disease. A significant
contributing factor to the progression of the disease appears to be the progressive …

Background Microglia are active modulators of Alzheimer's disease but their role in relation
to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add …

Alzheimer's disease (AD) has been associated with the hallmark features of cholinergic
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

Soluble amyloid-β (Aβ) is considered to be a critical component in the pathogenesis of
Alzheimer's disease (AD). Evidence suggests that these non-fibrillar Aβ assemblies are …

Alzheimer's disease (AD) causes the majority of dementia cases worldwide. Early
pathological hallmarks include the accumulation of amyloid-ß (Aß) and activation of both …

Amyloid-β (Aβ) peptides can form protease-resistant aggregates within and outside of
neurons. Accumulation of these aggregates is a hallmark of Alzheimer's disease (AD) …