Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Background Pyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique
ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly …

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to
isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we …

Objectives The purpose of this study was to determine the levels of isoniazid and
ethionamide resistance and to identify associated mutations in endemic multidrug-resistant …

Pyrazinamide (PZA) is a first-line antitubercular drug known for its activity against persistent
Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA …

Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA,
ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are …

SETTING: Western Cape and Eastern Cape Provinces, South Africa. OBJECTIVE: To assess
the potential association between the evolution of extensively drug-resistant (XDR) strains of …

Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant
(MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to …

Pyrazinamide (PZA) is a key component for the effective treatment of drug-susceptible and
PZA-susceptible multidrug-resistant (MDRPZA-S) tuberculosis (TB). pncA gene mutations …

Objectives To determine the prevalence of isoniazid resistance-conferring mutations among
multidrug-resistant (MDR) isolates of Mycobacterium tuberculosis from Poland. Methods …