Fibrillar collagen: a review of the mechanical modeling of strain-mediated enzymatic turnover

H Topol, H Demirkoparan… - Applied …, 2021 - asmedigitalcollection.asme.org
Collagen is the most abundant protein in mammals, often serving as the main load bearing
constituent in soft tissues. Collagen undergoes continuous remodeling processes in which …

[HTML][HTML] On modeling the multiscale mechanobiology of soft tissues: Challenges and progress

Y Guo, MRK Mofrad, AB Tepole - Biophysics Reviews, 2022 - pubs.aip.org
Tissues grow and remodel in response to mechanical cues, extracellular and intracellular
signals experienced through various biological events, from the developing embryo to …

A microstructurally based continuum model of cartilage viscoelasticity and permeability incorporating measured statistical fiber orientations

DM Pierce, MJ Unterberger, W Trobin, T Ricken… - … and modeling in …, 2016 - Springer
The remarkable mechanical properties of cartilage derive from an interplay of isotropically
distributed, densely packed and negatively charged proteoglycans; a highly anisotropic and …

[HTML][HTML] Bulging of inflated membranes made of fiber reinforced materials with different natural configurations

H Topol, NK Jha, H Demirkoparan, M Stoffel… - European Journal of …, 2022 - Elsevier
In this article, we study the inflation and bulging of fiber reinforced hyperelastic membranes
in which fibers are symmetrically arranged in two helically distributed families that are …

Bifurcation of Fiber-Reinforced Cylindrical Membranes under‎ Extension, Inflation, and Swelling

H Topol, MJ Al-Chlaihawi, H Demirkoparan… - Journal of Applied and …, 2023 - jacm.scu.ac.ir
We analyze bifurcation for a cylindrical membrane capable of swelling subjected to
combined axial loading and internal pressure. The material is conceptualized as an isotropic …

Nonlinear mechanics of remodeling

A Kumar, A Yavari - Journal of the Mechanics and Physics of Solids, 2023 - Elsevier
In this paper, we present a large-deformation formulation of the mechanics of remodeling.
Remodeling is anelasticity with an internal constraint—material evolutions that are mass and …

[HTML][HTML] On collagen fiber morphoelasticity and homeostatic remodeling tone

H Topol, H Demirkoparan, TJ Pence - Journal of the Mechanical Behavior of …, 2021 - Elsevier
A variety of biochemical and physical processes participate in the creation and maintenance
of collagen in biological tissue. Under mechanical stimuli these collagen fibers undergo …

Sensitivity analysis of fibrous thick-walled tubes with mechano-sensitive remodeling fibers in homeostasis

H Asghari, H Topol, J Lacalle, J Merodio - Acta Mechanica, 2024 - Springer
In this article, we apply the sensitivity analysis method to capture the influence of various
parameters on the inflation pressure, axial force, and the deformation for an inflated and …

Morphoelastic fiber remodeling in pressurized thick-walled cylinders with application to soft tissue collagenous tubes

H Topol, H Demirkoparan, TJ Pence - European Journal of Mechanics-A …, 2019 - Elsevier
We consider the mechanics of fiber remodeling in a pressurized thick walled cylinder where
our focus is on the interaction between inflation and remodeling. The material is taken to …

A micromechanical model for the growth of collagenous tissues under mechanics-mediated collagen deposition and degradation

Z Jia, TD Nguyen - Journal of the mechanical behavior of biomedical …, 2019 - Elsevier
In this study, we developed a micromechanical model for the growth and remodeling of a
soft tissue based on the concurrent action of collagen deposition and degradation. We …