Simple Summary Mesenchymal stromal/stem cells have intrinsic antimicrobial properties,
thus making them attractive as an alternative treatment strategy in chronic, drug-resistant …

Background: Early intervention with mesenchymal stem cells (MSCs) after articular trauma
has the potential to limit progression of focal lesions and prevent ongoing cartilage …

Stem cells are of great interest in tissue regeneration due to their ability to modulate the local
microenvironment by secreting bioactive factors (collectively, secretome). However …

Background Rapid development of antibiotic resistance necessitates advancement of novel
therapeutic strategies to treat infection. Mesenchymal stromal cells (MSC) possess …

Platelet-rich plasma (PRP) preparations are being used with moderate success to treat
osteoarthritis (OA) in humans and in veterinary species. Such preparations are hindered …

Equine osteoarthritis (OA) leads to cartilage degradation with impaired animal well-being,
premature cessation of sport activity, and financial losses. Mesenchymal stem cell (MSC) …

With an intrinsically low ability for self-repair, articular cartilage injuries often progress to
cartilage loss and joint degeneration resulting in osteoarthritis (OA). Osteoarthritis and the …

Background Lameness is a debilitating condition in equine athletes that leads to more
performance limitation and loss of use than any other medical condition. There are a limited …

Background TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin,
possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide …

Lubricin, a glycoprotein encoded by the proteoglycan 4 (PRG4) gene, is an essential
boundary lubricant that reduces friction between articular cartilage surfaces. The loss of …