Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism

Y Lv, T Liang, G Wang, Z Li - Bioscience reports, 2018 - portlandpress.com
Ghrelin, an acylated peptide hormone of 28 amino acids, is an endogenous ligand of the
released growth hormone secretagogue receptor (GHSR). Ghrelin has been isolated from …

The impact of ghrelin in metabolic diseases: an immune perspective

JAS Pereira, FC Silva… - Journal of diabetes …, 2017 - Wiley Online Library
Obesity and insulin resistance have reached epidemic proportions. Obesogenic conditions
are associated with increased risk for the development of other comorbidities and obesity …

Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation

DM Kim, JH Lee, Q Pan, HW Han, Z Shen… - Molecular …, 2024 - Elsevier
Objective Obesity-associated chronic inflammation, aka meta-inflammation, is a key
pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue …

[HTML][HTML] Ghrelin and cancer progression

TC Lin, M Hsiao - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Ghrelin is a small peptide with 28 amino acids, and has been characterized as the ligand of
the growth hormone secretagogue receptor (GHSR). In addition to its original function in …

The drug likeness analysis of anti-inflammatory clerodane diterpenoids

Z Feng, J Cao, Q Zhang, L Lin - Chinese medicine, 2020 - Springer
Inflammation is an active defense response of the body against external stimuli. Long term
low-grade inflammation has been considered as a deteriorated factor for aging, cancer …

Role and molecular mechanism of ghrelin in degenerative musculoskeletal disorders

J Sun, Y Tan, J Su, H Mikhail, V Pavel… - Journal of Cellular …, 2023 - Wiley Online Library
Ghrelin is a brain‐gut peptide, and the first 28‐peptide that was found in the gastric mucosa.
It has a growth hormone (GH)‐releasing hormone‐like effect and can potently promote the …

Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome …

C Chen, Y Ren, J Zhu, J Chen, Z Feng… - Acta Pharmacologica …, 2022 - nature.com
Abstract Interleukin-1β (IL-1β), a key pro-inflammatory cytokine, is majorly produced by
macrophages through NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) …

Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low‐grade inflammation via blockade of Kupffer cell M1 polarization

Y Yin, Q Wang, M Qi, C Zhang, Z Li… - Journal of cellular …, 2021 - Wiley Online Library
Whether the stomach influences the progression of nonalcoholic steatohepatitis (NASH)
remains largely unknown. Ghrelin, a 28‐amino acid gastric hormone, is critical for the …

Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis

CS Wu, OYN Bongmba, J Yue, JH Lee, L Lin… - International journal of …, 2017 - mdpi.com
Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to
stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin …

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

AH Lékó, A Gregory-Flores, RCN Marchette… - Communications …, 2024 - nature.com
The stomach-derived hormone ghrelin regulates essential physiological functions. The
ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion …