Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)

O Ristow, S Otto, M Troeltzsch… - Journal of Cranio …, 2015 - Elsevier
The medication-related osteonecrosis of the jaw (MRONJ) is believed to be a therapy-
resistant entity. Although the application of the recommended conservative and surgical …

Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development?

S Otto, M Tröltzsch, V Jambrovic, S Panya… - Journal of Cranio …, 2015 - Elsevier
Introduction Scientific debate outlines tooth extraction as a potential trigger for the onset of
bisphosphonate-related osteonecrosis of the jaw (BRONJ). Therefore, the aim of this study …

A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral …

T Hasegawa, A Kawakita, N Ueda, R Funahara… - Osteoporosis …, 2017 - Springer
Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an
unclosed wound were significantly associated with increased risk of developing medication …

Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease

A Soundia, D Hadaya, N Esfandi, RS de Molon… - Bone, 2016 - Elsevier
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as
denosumab or bisphosphonates, prescribed to patients with bone malignancy or …

Medication-related osteonecrosis of the jaw: a critical narrative review

AI Lorenzo-Pouso, J Bagán, L Bagán… - Journal of Clinical …, 2021 - mdpi.com
Background: Nearly two decades have passed since a paradoxical reaction in the orofacial
region to some bone modifying agents and other drugs was recognized, namely medication …

Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

H Hadad, HR Matheus, SI Pai, FA Souza… - Archives of Oral …, 2024 - Elsevier
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …

Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials

H Holtmann, J Lommen, NR Kübler… - Journal of …, 2018 - journals.sagepub.com
Objective This study was performed to determine whether the results of prevailing in vivo
and in vitro studies offer a reliable model for investigation of medication-related …

Etiopathogenesis of medication-related osteonecrosis of the jaws: a review

G Bassan Marinho Maciel, R Marinho Maciel… - Journal of Molecular …, 2024 - Springer
This study compiles the main hypotheses involved in the etiopathogenesis of medication-
related osteonecrosis of the jaw (MRONJ). A narrative review of the literature was …

In vivo effects of geranylgeraniol on the development of bisphosphonate-related osteonecrosis of the jaws

F Koneski, D Popovic-Monevska, I Gjorgoski… - Journal of Cranio …, 2018 - Elsevier
Background Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a complication of
the bisphosphonate (BP) treatment and its pathopysiology is still not fully understood. The …