Protease allergens as initiators–regulators of allergic inflammation
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …
harmless environmental proteins from different origins can induce potent Th2‐biased …
The microbiome and food allergy
The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …
[HTML][HTML] Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
Pathophysiology of non-IgE-mediated food allergy
S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets
F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
Alpha‐1‐antitrypsin: a possible host protective factor against Covid‐19
MB de Loyola, TTA Dos Reis… - Reviews in medical …, 2021 - Wiley Online Library
Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …
Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …
Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
H Li, P Liu, B Zhang, Z Yuan, M Guo, X Zou, Y Qian… - Genome Medicine, 2023 - Springer
Background Damage in the ischemic core and penumbra after stroke affects patient
prognosis. Microglia immediately respond to ischemic insult and initiate immune …
prognosis. Microglia immediately respond to ischemic insult and initiate immune …
Eosinophilic esophagitis: Immune mechanisms and therapeutic targets
D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
Breaking down the complex pathophysiology of eosinophilic esophagitis
B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …