Protease allergens as initiators–regulators of allergic inflammation

WT Soh, J Zhang, MD Hollenberg, H Vliagoftis… - Allergy, 2023 - Wiley Online Library
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

The microbiome and food allergy

OI Iweala, CR Nagler - Annual review of immunology, 2019 - annualreviews.org
The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …

[HTML][HTML] Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation

M Rochman, T Wen, M Kotliar, PJ Dexheimer… - JCI insight, 2022 - ncbi.nlm.nih.gov
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …

Pathophysiology of non-IgE-mediated food allergy

S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …

Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Alpha‐1‐antitrypsin: a possible host protective factor against Covid‐19

MB de Loyola, TTA Dos Reis… - Reviews in medical …, 2021 - Wiley Online Library
Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …

Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

Acute ischemia induces spatially and transcriptionally distinct microglial subclusters

H Li, P Liu, B Zhang, Z Yuan, M Guo, X Zou, Y Qian… - Genome Medicine, 2023 - Springer
Background Damage in the ischemic core and penumbra after stroke affects patient
prognosis. Microglia immediately respond to ischemic insult and initiate immune …

Eosinophilic esophagitis: Immune mechanisms and therapeutic targets

D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …

Breaking down the complex pathophysiology of eosinophilic esophagitis

B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …