Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

S Deleu, K Machiels, J Raes, K Verbeke, S Vermeire - EBioMedicine, 2021 - thelancet.com
The gut microbiome and the intestinal immune system are driving contributors to
inflammatory bowel diseases (IBD). Both have an important signalling factor in common …

Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

PT Santana, SLB Rosas, BE Ribeiro, Y Marinho… - International journal of …, 2022 - mdpi.com
Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Z Wu, S Huang, T Li, N Li, D Han, B Zhang, ZZ Xu… - Microbiome, 2021 - Springer
Background Alteration of the gut microbiota may contribute to the development of
inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive …

[HTML][HTML] Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

J Wu, Z Wei, P Cheng, C Qian, F Xu, Y Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases
(IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut …

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

C Zhang, J Li, M Xiao, D Wang, Y Qu, L Zou… - Chinese Chemical …, 2022 - Elsevier
Although multitudinous nanoscale drug-delivery systems (DDSs) have been recommended
to improve anti-ulcerative colitis (UC) outcomes, to enhance the mucoadhesion of …

Inflammatory bowel disease presentation and diagnosis

S Flynn, S Eisenstein - Surgical Clinics, 2019 - surgical.theclinics.com
Inflammatory bowel disease (IBD) is the continuum of diseases that comprise Crohn's
disease (CD), ulcerative colitis (UC), and indeterminate colitis. The incidence of IBD has …

[PDF][PDF] Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation

SR Sinha, Y Haileselassie, LP Nguyen, C Tropini… - Cell host & …, 2020 - cell.com
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Y Ouyang, J Zhao, S Wang - International journal of biological …, 2023 - Elsevier
Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Oral zero-valent-molybdenum nanodots for inflammatory bowel disease therapy

C Zhang, H Wang, X Yang, Z Fu, X Ji, Y Shi… - Science …, 2022 - science.org
Inflammatory bowel disease (IBD) affects millions of people each year. The overproduction
of reactive oxygen species (ROS) plays a critical role in the progress of IBD and will be a …