Recent advancements in gene supplementation therapy are expanding the options for the
treatment of neurological disorders. Among the available delivery vehicles, adeno …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Activity-dependent translation requires the transport of mRNAs within membraneless protein
assemblies known as neuronal granules from the cell body toward synaptic regions …

Fragile X syndrome (FXS) is the most common single gene cause of autism and intellectual
disabilities. Humans with FXS exhibit increased anxiety, sensory hypersensitivity, seizures …

Neonicotinoids have become the most widely used class of insecticides world-wide.
Although numerous studies have documented neonicotinoid toxicity in bees and other …

Fragile X syndrome, the leading heritable form of intellectual disability, is caused by
hypermethylation and transcriptional silencing of large (CGG) repeat expansions (> 200 …

Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Autism spectrum disorders (ASD) are complex neurodevelopmental disorders that are
caused by genetic and/or environmental impacts, often probably by the interaction of both …

Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or
hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS), the most common …

Principal neurons encode information by varying their firing rate and patterns precisely fine-
tuned through GABAergic interneurons. Dysregulation of inhibition can lead to …