The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Following its benchmark discovery, nitric oxide (NO) is now known to play important
functional roles in a variety of physiological systems. Within the vasculature, NO induces …

Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types
and organ systems. In the cardiovascular system, NO is an important determinant of basal …

Vascular aging is mainly characterized by endothelial dysfunction. We found decreased free
nitric oxide (NO) levels in aged rat aortas, in conjunction with a sevenfold higher expression …

Endothelial nitric-oxide synthase (eNOS) and caveolin-1 are associated within endothelial
plasmalemmal caveolae. It is not known, however, whether eNOS and caveolin-1 interact …

Nitric oxide (NO) is a potent vasodilator that was initially described as the mediator of
endothelium-dependent relaxation (endothelium-derived relaxing factor, EDRF). It is now …

Introduction 3. Discovery of NO 3.1. Nitric oxide and the Nobel prize 3.2. NO generation and
nitric oxide synthase 3.2. 1. eNOS 3.2. 2. iNOS 3.2. 3. nNOS 3.3. Nitrovasodilators 4. NO …

Nitric oxide, a key signaling molecule, is produced by a family of enzymes collectively called
nitric oxide synthases (NOS). Here, we report the crystal structure of the heme domain of …

Nitric oxide (NO) is produced in physiological and pathophysiological conditions by three
distinct isoforms of NO synthase (NOS): endothelial NOS (ecNOS), inducible NOS (iNOS) …

The biosynthesis and release of nitric oxide (NO) and prostaglandins (PGs) share a number
of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) …