In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

Both circuit and single-cell properties contribute to network rhythms. In vitro, pyramidal cells
exhibit theta-band membrane potential (subthreshold) resonance, but whether and how …

Hyperpolarization‐activated cation currents (Ih) contribute to various physiological
properties and functions in the brain, including neuronal pacemaker activity, setting of …

This article addresses the functional significance of the electrophysiological properties of
thalamic neurons. We propose that thalamocortical activity, is the product of the intrinsic …

Hyperpolarization‐activated cation (HCN) channels are believed to be involved in the
generation of cardiac pacemaker depolarizations as well as in the control of neuronal …