Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Colubrid venom composition: an-omics perspective

ILM Junqueira-de-Azevedo, PF Campos, ATC Ching… - Toxins, 2016 - mdpi.com
Snake venoms have been subjected to increasingly sensitive analyses for well over 100
years, but most research has been restricted to front-fanged snakes, which actually …

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of …

S Ainsworth, D Petras, M Engmark, RD Süssmuth… - Journal of …, 2018 - Elsevier
Mambas (genus Dendroaspis) are among the most feared of the medically important elapid
snakes found in sub-Saharan Africa, but many facets of their biology, including the diversity …

Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom …

LF Sousa, CN Zdenek, JS Dobson, B Op den Brouw… - Toxins, 2018 - mdpi.com
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important
group responsible for the greatest number of snakebite envenomations and deaths in South …

Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Oxyuranus spp.) and Brown Snakes (Pseudonaja spp.)

J van Thiel, LL Alonso, J Slagboom, N Dunstan… - Toxins, 2023 - mdpi.com
Snake venoms are complex mixtures of toxins that differ on interspecific (between species)
and intraspecific (within species) levels. Whether venom variation within a group of closely …

Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)

V Cipriani, J Debono, J Goldenberg… - … and Physiology Part C …, 2017 - Elsevier
Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution
across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly …

Rapid radiations and the race to redundancy: An investigation of the evolution of Australian elapid snake venoms

TNW Jackson, I Koludarov, SA Ali, J Dobson… - Toxins, 2016 - mdpi.com
Australia is the stronghold of the front-fanged venomous snake family Elapidae. The
Australasian elapid snake radiation, which includes approximately 100 terrestrial species in …

[HTML][HTML] What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the …

D Pla, L Sanz, G Whiteley, SC Wagstaff… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background Non-front-fanged colubroid snakes comprise about two-thirds of extant
ophidian species. The medical significance of the majority of these snakes is unknown, but …

An appetite for destruction: Detecting prey-selective binding of α-neurotoxins in the venom of Afro-Asian elapids

RJ Harris, CN Zdenek, D Harrich, N Frank, BG Fry - Toxins, 2020 - mdpi.com
Prey-selective venoms and toxins have been documented across only a few species of
snakes. The lack of research in this area has been due to the absence of suitably flexible …

The snake with the scorpion's sting: Novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

DC Yang, JR Deuis, D Dashevsky, J Dobson… - Toxins, 2016 - mdpi.com
Millions of years of evolution have fine-tuned the ability of venom peptides to rapidly
incapacitate both prey and potential predators. Toxicofera reptiles are characterized by …