Advances in targeting the folate receptor in the treatment/imaging of cancers

M Fernández, F Javaid, V Chudasama - Chemical science, 2018 - pubs.rsc.org
The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …

Metallodrugs in medicinal inorganic chemistry

KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Clinically approved nanoparticle imaging agents

AS Thakor, JV Jokerst, P Ghanouni… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Nanoparticles are a new class of imaging agent used for both anatomic and molecular
imaging. Nanoparticle-based imaging exploits the signal intensity, stability, and …

Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides

S Liu - Advanced drug delivery reviews, 2008 - Elsevier
Receptor-based radiopharmaceuticals are of great current interest in molecular imaging and
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …

Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era

MD Bartholoma, AS Louie, JF Valliant… - Chemical …, 2010 - ACS Publications
The objective of medical imaging using molecular probes and perfusion radiotracers is to
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …

The role of coordination chemistry in the development of target-specific radiopharmaceuticals

S Liu - Chemical Society Reviews, 2004 - pubs.rsc.org
There is a great current interest in developing target-specific radiopharmaceuticals for early
detection of diseases and radiotherapy of cancers. This critical review will focus on the role …

Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer

M Hamoudeh, MA Kamleh, R Diab, H Fessi - Advanced drug delivery …, 2008 - Elsevier
The recent developments of nuclear medicine in oncology have involved numerous
investigations of novel specific tumor-targeting radiopharmaceuticals as a major area of …

Recent advances in radiometals for combined imaging and therapy in cancer

N Herrero Álvarez, D Bauer, J Hernández‐Gil… - …, 2021 - Wiley Online Library
Nuclear medicine is defined as the use of radionuclides for diagnostic and therapeutic
applications. The imaging modalities positron emission tomography (PET) and single …

A nuclear chocolate box: the periodic table of nuclear medicine

PJ Blower - Dalton Transactions, 2015 - pubs.rsc.org
Radioisotopes of elements from all parts of the periodic table find both clinical and research
applications in radionuclide molecular imaging and therapy (nuclear medicine). This article …

Role of Pure Technetium Chemistry: Are There Still Links to Applications in Imaging?

R Alberto - Inorganic Chemistry, 2023 - ACS Publications
The discovery and development of new 99mTc-based radiopharmaceuticals or labeled
drugs in general is based on innovative, pure chemistry and subsequent, application …