Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by
the known mechanisms of action of the offending agent, do not occur at any dose in most …

Introduction. Valproic acid (VPA) is a broad-spectrum antiepileptic drug that is now used
commonly for several other neurological and psychiatric indications. VPA is usually well …

Valproate‐induced hyperammonemic encephalopathy (VHE) is an unusual complication
characterized by a decreasing level of consciousness, focal neurological deficits, cognitive …

Background–Drug‐induced liver injury associated with antiepileptic drugs (AED) is well
recognized. The frequency of the most common AED is rare but the consequences can be …

Antiepileptic drugs (AEDs) are no longer restricted to the treatment of epilepsy. These are
widely used in a broad spectrum of psychiatric and neurological disorders. Liver plays a …

INTRODUCTION: Valproate (VPA)-induced hyperammonemic encephalopathy (VHE) is a
serious drug-related adverse effect characterized by lethargy, vomiting, cognitive slowing …

Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well-tolerated.
Rare serious complications may occur in some patients, including haemorrhagic …

In 1980 Coulter and Allen (1) reported the first case of hyperammonemia, to our knowledge,
with otherwise normal hepatic function tests in a child with epilepsy treated with valproic …

Antiepileptic drugs (AEDs) are a class of medications that have received considerable
attention as possible treatments for agitation and aggression in patients with dementia. This …

Hyperammonemia (HA) commonly occurs with the use of valproic acid (VPA); while it has no
clinical significance in most cases, the Physician Desk Reference recommends its …