Inflammasome activation in the central nervous system occurs in both health and disease.
Inflammasomes are cytosolic protein complexes that sense specific infectious or host stimuli …

Multiple sclerosis is a neurologic disease caused by immune cell infiltration into the central
nervous system, resulting in gray and white matter inflammation, progressive demyelination …

The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's
disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that …

Multiple sclerosis (MS), and its animal model experimental autoimmune encephalomyelitis,
are neuroinflammatory diseases driven by autoreactive pathogenic TH cells that elicit …

The aptly named inflammasomes are powerful signaling complexes that sense inflammatory
signals under a myriad of conditions, including those from infections and endogenous …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …

IL-1β and IL-18 are pro-inflammatory cytokines that are linked to inflammation. Activation of
the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the maturation and …

Fractalkine (CX3CL1 or FKN) is a membrane-bound chemokine expressed on neuronal
membranes and is proteolytically cleaved to shed a soluble chemoattractant domain. FKN …

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in numerous metabolic
pathways, and so may support protective and reparative processes against central nervous …

The present article reviews and compares the immunomodulatory activities of Crocus
sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds …