Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

Stroke is an important disease with unmet clinical need. To uncover novel paths for
treatment, it is of critical importance to develop relevant laboratory models that may help to …

Summary Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for
extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac …

Cardiac hypertrophy is a condition that may contribute to the development of heart failure. In
this study, we compare the gene-expression patterns of our in vitro stem-cell-based cardiac …

One of the many unresolved obstacles in the field of cardiovascular research is an
uncompromising in vitro cardiac model. While primary cell sources from animal models offer …

Cardiac hypertrophy is an important and independent risk factor for the development of
cardiomyopathy that may lead to heart failure. To accelerate the development of new and …

Heparan sulfate proteoglycans (HSPGs) contribute to structural integrity and signalling
regulation during cardiac development, healing, and wound repair, one such HSPG being …