The high-affinity Fc receptor for IgE (FcεRI), a multimeric immune receptor, is a crucial
structure for IgE-mediated allergic reactions. In recent years, advances have been made in …

FcγRs have been the focus of extensive research due to their key role linking innate and
humoral immunity and their implication in both inflammatory and infectious disease. Within …

Since an immunoreceptor tyrosine‐based inhibition motif (ITIM) was first identified in the
intracytoplasmic domain of FcγRIIB, ITIMs have been found in a large number of inhibitory …

Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system,
mediating functions as diverse as phagocytosis, triggering degranulation of basophils and …

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation.
Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced …

Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a
signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co …

BACKGROUND: Sialic acid–binding immunoglobulin-like lectins (Siglecs) are a family of
glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on …

Mast cells are effector cells of the innate immune system, but because they express Fc
receptors (FcRs), they can be engaged in adaptive immunity by antibodies. Mast cell FcRs …

Objective To exploit the physiologic Fcγ receptor IIb (CD32B) inhibitory coupling mechanism
to control B cell activation by constructing a novel bispecific diabody scaffold, termed a dual …

Abstract The enzyme indoleamine 2, 3‐dioxygenase 1 (IDO 1) catalyses the initial, rate‐
limiting step in tryptophan (Trp) degradation, resulting in tryptophan starvation and the …