Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Noncovalent interactions are essential for the existence of solid and liquid phases. 1, 2
Traditionally touted as weak forces, quantification of these interactions, which govern the …

Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Cation–π interactions are common in nature, especially in organisms. Their profound
influences in chemistry, physics, and biology have been continuously investigated since …

Forces to reckon with: Supramolecular complexes, such as the one shown, are normally
based on a combination of different interactions such as ion pairing, hydrogen bonds, and …

The influence of a xenobiotic compound on an organism is usually summarized by the
expression biological activity. If a controlled, therapeutically relevant, and regulatory action …

One type of important noncovalent interactions in biological systems is the cation–π
interaction that is widely present between an electron-rich π system (eg, Phe, Tyr, and Trp) …

Abstract Zwischenmolekulare Wechselwirkungen unter Beteiligung aromatischer Ringe sind
Schlüsselvorgänge sowohl in chemischen als auch in biologischen Erkennungsprozessen …

Cation-π interaction is considered one of the strongest noncovalent interactions in aqueous
solutions, which endows natural biomolecules (eg, proteins) with robust wet adhesion and …

Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …