Betulin and betulinic acid: Triterpenoids derivatives with a powerful biological potential

A Hordyjewska, A Ostapiuk, A Horecka… - Phytochemistry …, 2019 - Springer
Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Ursolic acid and its derivatives as bioactive agents

S Mlala, AO Oyedeji, M Gondwe, OO Oyedeji - Molecules, 2019 - mdpi.com
Non-communicable diseases (NCDs) such as cancer, diabetes, and chronic respiratory and
cardiovascular diseases continue to be threatening and deadly to human kind. Resistance …

Ursolic acid-based derivatives as potential anti-cancer agents: An update

V Khwaza, OO Oyedeji, BA Aderibigbe - International journal of molecular …, 2020 - mdpi.com
Ursolic acid is a pharmacologically active pentacyclic triterpenoid derived from medicinal
plants, fruit, and vegetables. The pharmacological activities of ursolic acid have been …

Ursolic acid (UA): A metabolite with promising therapeutic potential

D Kashyap, HS Tuli, AK Sharma - Life sciences, 2016 - Elsevier
Plants are known to produce a variety of bioactive metabolites which are being used to cure
various life threatening and chronic diseases. The molecular mechanism of action of such …

Terpenoids as potential geroprotectors

E Proshkina, S Plyusnin, T Babak, E Lashmanova… - Antioxidants, 2020 - mdpi.com
Terpenes and terpenoids are the largest groups of plant secondary metabolites. However,
unlike polyphenols, they are rarely associated with geroprotective properties. Here we …

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

MK Shanmugam, AH Nguyen, AP Kumar, BKH Tan… - Cancer letters, 2012 - Elsevier
Over the last two decades, extensive research on plant-based medicinal compounds has
revealed exciting and important pharmacological properties and activities of triterpenoids …

The possible role of ursolic acid in Covid-19: a real game changer

HM Al-Kuraishy, AI Al-Gareeb, GES Batiha - Clinical nutrition ESPEN, 2022 - Elsevier
Ursolic acid (UA) is a pentacyclic terpenoid is usually found in the fruit peels and stem bark
as secondary metabolites. UA has antiviral, antibacterial, and antiparasitic properties. UA …

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

HM Al-Kuraishy, AI Al-Gareeb, WA Negm… - …, 2022 - Springer
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) has been
identified as the source of a world coronavirus pandemic in 2019. Covid-19 is considered a …

Cheminformatics-based study identifies potential ebola VP40 inhibitors

E Broni, C Ashley, J Adams, H Manu, E Aikins… - International Journal of …, 2023 - mdpi.com
The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in
primates. However, there are no regulatorily approved drugs against the Ebola virus disease …