Multiple sclerosis epidemiological trends in Italy highlight the environmental risk factors
M Puthenparampil, P Perini, R Bergamaschi… - Journal of …, 2022 - Springer
Italy is definitely a high-risk country for multiple sclerosis (MS). Over the last 50 years,
several epidemiological studies, including longitudinal surveys, have disclosed that MS …
several epidemiological studies, including longitudinal surveys, have disclosed that MS …
The origin and legacy of the Etruscans through a 2000-year archeogenomic time transect
The origin, development, and legacy of the enigmatic Etruscan civilization from the central
region of the Italian peninsula known as Etruria have been debated for centuries. Here we …
region of the Italian peninsula known as Etruria have been debated for centuries. Here we …
Inferring signatures of positive selection in whole-genome sequencing data: an overview of haplotype-based methods
Signatures of positive selection in the genome are a characteristic mark of adaptation that
can reveal an ongoing, recent, or ancient response to environmental change throughout the …
can reveal an ongoing, recent, or ancient response to environmental change throughout the …
Whole-genome sequencing analysis of semi-supercentenarians
P Garagnani, J Marquis, M Delledonne, C Pirazzini… - Elife, 2021 - elifesciences.org
Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …
decades of human life avoided or largely postponed all major age-related diseases. In this …
Amyloid precursor protein A713T mutation in Calabrian patients with Alzheimer's Disease: A population genomics approach to estimate inheritance from a common …
Mutation A713T in the amyloid precursor protein (APP) has been linked to cases of
Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease …
Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease …
The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains
A Modi, H Lancioni, I Cardinali, MR Capodiferro… - Scientific reports, 2020 - nature.com
Umbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri,
whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) …
whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) …
Apolipoprotein E (APOE) haplotypes in healthy subjects from worldwide macroareas: A population genetics perspective for cardiovascular disease …
Human APOE is a 299-amino acid long protein expressed and secreted in several tissues
and body districts, where it exerts different functions mainly related to lipid metabolism, with …
and body districts, where it exerts different functions mainly related to lipid metabolism, with …
Through 40,000 years of human presence in Southern Europe: the Italian case study
Abstract The Italian Peninsula, a natural pier across the Mediterranean Sea, witnessed
intricate population events since the very beginning of the human occupation in Europe. In …
intricate population events since the very beginning of the human occupation in Europe. In …
Rare amyloid precursor protein point mutations recapitulate worldwide migration and admixture in healthy individuals: Implications for the study of neurodegeneration
Genetic discoveries related to Alzheimer's disease and other dementias have been
performed using either large cohorts of affected subjects or multiple individuals from the …
performed using either large cohorts of affected subjects or multiple individuals from the …
Longer leukocytes telomere length predicts a significant survival advantage in the elderly TRELONG cohort, with short physical performance battery score and years of …
S Pavanello, M Campisi, A Grassi… - Journal of Clinical …, 2021 - mdpi.com
Leukocyte telomere length (LTL) represents a key integrating component of the cumulative
effects of environmental, lifestyle, and genetic factors. A question, however, remains on …
effects of environmental, lifestyle, and genetic factors. A question, however, remains on …