Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

Viruses may contribute to the development of human tumors by different mechanisms:
indirectly by inducing immunosuppression or by modifying the host cell genome without …

Chronic hepatitis B virus (HBV) infection is prevalent, deadly and seldom cured due to the
persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome …

Although threshold levels for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen
(HBeAg) titers have recently been proposed to guide therapy for chronic hepatitis B (CHB) …

With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …

BACKGROUND & AIMS: Data from clinical trials suggest a potential role for on-treatment
monitoring of serum HBsAg titres during interferon-alpha (pegIFN) therapy in predicting …

Abstract HEPATITIS B virus (HBV) DNA frequently integrates into the genome of human
primary liver cancer cells1–4, but the significance of this integration in liver carcinogenesis is …

Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma
(HCC). Individuals who are chronic carriers have a greater than 100‐fold increased relative …

Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular
genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have …

Hepatocellular carcinoma (HCC) is the most common histological form of primary liver
cancer, the tumor cells having retained features of hepatocytic differentiation. It is important …