Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …

Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Osteoarthritis (OA) is a common degenerative joint disorder, which involves articular
cartilage degeneration as well as joint inflammatory reactions. The recent studies have …

More than 30 neurodegenerative diseases including Alzheimer disease (AD),
frontotemporal lobe dementia (FTD), and some forms of Parkinson disease (PD) are …

Programmed cell death (PCD) is probably the most widely discussed subject among the
topics of cancer therapy. Over the last 2 decades an astonishing boost in our perception of …

Glycogen synthase kinase-3 (GSK3) are ubiquitously expressed serine-threonine kinases
involved in a plethora of functions ranging from the control of glycogen metabolism to …

Alzheimer's disease (AD) has been associated with altered activity of glycogen synthase
kinase 3 (GSK3) isozymes, which are proposed to contribute to both neurofibrillary tangles …

Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective mechanisms,
including autophagy regulation, in various neuropsychiatric conditions. In …