The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

Background The intestinal microbiota plays an important role in regulating gastrointestinal
(GI) physiology in part through interactions with the enteric nervous system (ENS) …

The enteric nervous system (ENS) is crucial for essential gastrointestinal physiologic
functions such as motility, fluid secretion, and blood flow. The gut is colonized by trillions of …

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …

Mucosal barrier immunity is essential for the maintenance of the commensal microflora and
combating invasive bacterial infection. Although immune and epithelial cells are thought to …

Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the
“support” cells of the enteric nervous system, studies over the past 20 years have unveiled a …

Background The intestine is known to contain enteric neuronal progenitors, but their precise
identity and the mechanisms that activate them remain unknown. Based on the evidence for …

Mechanisms mediating adult enteric neurogenesis are largely unknown. Using inflammation-
associated neurogenesis models and a transgenic approach, we aimed to understand the …