How I treat pediatric acute myeloid leukemia
JE Rubnitz, GJL Kaspers - Blood, The Journal of the American …, 2021 - ashpublications.org
Abstract Treatment outcomes for pediatric patients with acute myeloid leukemia (AML) have
continued to lag behind outcomes reported for children with acute lymphoblastic leukemia …
continued to lag behind outcomes reported for children with acute lymphoblastic leukemia …
Acute myeloid leukemia
JE Rubnitz, B Gibson, FO Smith - Pediatric clinics of North America, 2008 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal
transformation of hematopoietic precursors through the acquisition of chromosomal …
transformation of hematopoietic precursors through the acquisition of chromosomal …
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
We present the molecular landscape of pediatric acute myeloid leukemia (AML) and
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …
characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The …
Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012
M Rasche, M Zimmermann, L Borschel, JP Bourquin… - Leukemia, 2018 - nature.com
Overall survival (OS) of pediatric patients with acute myeloid leukemia (AML) increased in
recent decades. However, it remained unknown whether advances in first-line treatment …
recent decades. However, it remained unknown whether advances in first-line treatment …
NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia
JE Rubnitz, H Inaba, RC Ribeiro, S Pounds… - Journal of clinical …, 2010 - ascopubs.org
Purpose To conduct a pilot study to determine the safety, feasibility, and engraftment of
haploidentical natural killer (NK) cell infusions after an immunosuppressive regimen in …
haploidentical natural killer (NK) cell infusions after an immunosuppressive regimen in …
Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial
JE Rubnitz, H Inaba, G Dahl, RC Ribeiro… - The lancet …, 2010 - thelancet.com
Background We sought to improve outcome in patients with childhood acute myeloid
leukaemia (AML) by applying risk-directed therapy that was based on genetic abnormalities …
leukaemia (AML) by applying risk-directed therapy that was based on genetic abnormalities …
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
BV Balgobind, SC Raimondi, J Harbott… - Blood, The Journal …, 2009 - ashpublications.org
Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid
leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is …
leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is …
Gemtuzumab Ozogamicin Improves Event-Free Survival and Reduces Relapse in Pediatric KMT2A-Rearranged AML: Results From the Phase III Children's Oncology …
PURPOSE We investigated the impact of the CD33-targeted agent gemtuzumab ozogamicin
(GO) on survival in pediatric patients with KMT2A-rearranged (KMT2A-r) acute myeloid …
(GO) on survival in pediatric patients with KMT2A-rearranged (KMT2A-r) acute myeloid …
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia: A …
RE van Weelderen, K Klein, CJ Harrison… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE A previous study by the International Berlin-Frankfurt-Münster Study Group (I-
BFM-SG) on childhood KMT2A-rearranged (KMT2A-r) AML demonstrated the prognostic …
BFM-SG) on childhood KMT2A-rearranged (KMT2A-r) AML demonstrated the prognostic …
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
F Mussai, S Egan… - Blood, The Journal …, 2015 - ashpublications.org
Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and
children, yet significant numbers of patients relapse and die of disease. In this study, we …
children, yet significant numbers of patients relapse and die of disease. In this study, we …