Glioblastoma and brain connectivity: the need for a paradigm shift

A Salvalaggio, L Pini, A Bertoldo… - The Lancet Neurology, 2024 - thelancet.com
Despite substantial advances in cancer treatment, for patients with glioblastoma prognosis
remains bleak. The emerging field of cancer neuroscience reveals intricate functional …

A prognostic neural epigenetic signature in high-grade glioma

R Drexler, R Khatri, T Sauvigny, M Mohme, CL Maire… - Nature Medicine, 2024 - nature.com
Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …

[HTML][HTML] Radio-Immunomics in Hepatocellular Carcinoma: Unraveling the Tumor Immune Microenvironment

Q Liu, W Zhu, F Song, T Lou, L He, W Zhou, Z Feng - Meta-Radiology, 2024 - Elsevier
Hepatocellular carcinoma (HCC) ranks as the sixth most prevalent and the fourth most lethal
malignancy worldwide, frequently manifesting at advanced stages with limited therapeutic …

Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion

E De Fazio, M Pittarello, A Gans, B Ghosh… - International journal of …, 2024 - mdpi.com
Gliomas are diffusely infiltrating brain tumors whose prognosis is strongly influenced by their
extent of invasion into the surrounding brain tissue. While lower-grade gliomas present more …

[HTML][HTML] Imaging and Liquid Biopsy for Distinguishing True Progression From Pseudoprogression in Gliomas, Current Advances and Challenges

K Li, Q Zhu, J Yang, Y Zheng, S Du, M Song, Q Peng… - Academic …, 2024 - Elsevier
Rationale and Objectives Gliomas are aggressive brain tumors with a poor prognosis.
Assessing treatment response is challenging because magnetic resonance imaging (MRI) …

Artificial Intelligence Imaging for Predicting High-risk Molecular Markers of Gliomas

Q Liang, H Jing, Y Shao, Y Wang, H Zhang - Clinical Neuroradiology, 2024 - Springer
Gliomas, the most prevalent primary malignant tumors of the central nervous system, present
significant challenges in diagnosis and prognosis. The fifth edition of the World Health …

[HTML][HTML] Revealing the biology behind MRI signatures in high grade glioma

EM Lewis, L Mao, L Wang, KR Swanson, RF Barajas… - medRxiv, 2023 - ncbi.nlm.nih.gov
Magnetic resonance imaging (MRI) measurements are routinely collected during the
treatment of high-grade gliomas (HGGs) to characterize tumor boundaries and guide …

[HTML][HTML] Androgen loss weakens anti-tumor immunity and accelerates brain tumor growth

J Lee, YM Chung, L Curtin, DJ Silver, Y Hao, C Li… - Research …, 2024 - ncbi.nlm.nih.gov
Many cancers, including glioblastoma (GBM), have a male-biased sex difference in
incidence and outcome. The underlying reasons for this sex bias are unclear but likely …

Insight into spatial intratumoral genomic evolution in glioblastoma

A Anand, JK Petersen, LB Andersen, M Burton… - bioRxiv, 2023 - biorxiv.org
Glioblastoma undergoes a complex and dynamic evolution involving genetic and epigenetic
changes. Understanding the mechanisms underlying this evolution is vital for the …

Differentiation Between High‐Grade Glioma and Brain Metastasis Using Cerebral Perfusion‐Related Parameters (Cerebral Blood Volume and Cerebral Blood Flow) …

S Mohammadi, S Ghaderi, AF Jouzdani… - Journal of Magnetic … - Wiley Online Library
Background Distinguishing high‐grade gliomas (HGGs) from brain metastases (BMs) using
perfusion‐weighted imaging (PWI) remains challenging. PWI offers quantitative …