Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease
ED Fowler, S Zissimopoulos - Biomolecules, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
Orai1 inhibitors as potential treatments for pulmonary arterial hypertension
B Masson, H Le Ribeuz, J Sabourin, L Laubry… - Circulation …, 2022 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal
pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure …
pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure …
The builders of the junction: roles of junctophilin1 and junctophilin2 in the assembly of the sarcoplasmic reticulum–plasma membrane junctions in striated muscle
S Perni - Biomolecules, 2022 - mdpi.com
Contraction of striated muscle is triggered by a massive release of calcium from the
sarcoplasmic reticulum (SR) into the cytoplasm. This intracellular calcium release is initiated …
sarcoplasmic reticulum (SR) into the cytoplasm. This intracellular calcium release is initiated …
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling
JB Xue, A Val-Blasco, M Davoodi, S Gómez… - Journal of General …, 2022 - rupress.org
Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart
failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma …
failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma …
Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Kir2. 1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1
Á Macías, A González-Guerra… - Nature Cardiovascular …, 2022 - nature.com
Andersen–Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of
unknown mechanism. In this study, we generated and characterized a mouse model of …
unknown mechanism. In this study, we generated and characterized a mouse model of …
Sarcoplasmic reticulum Ca2+ dysregulation in the pathophysiology of inherited arrhythmia: an update
Y Du, LJ Demillard, J Ren - Biochemical Pharmacology, 2022 - Elsevier
Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death
(SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic …
(SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic …
Local recovery of cardiac calcium‐induced calcium release interrogated by ultra‐effective, two‐photon uncaging of calcium
Key points In cardiac myocytes, subcellular local calcium release signals, calcium sparks,
are recruited to form each cellular calcium transient and activate the contractile machinery …
are recruited to form each cellular calcium transient and activate the contractile machinery …
Using hiPSC‐CMs to examine mechanisms of catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited cardiac arrhythmia condition, triggered by physical or acute emotional stress, that …
inherited cardiac arrhythmia condition, triggered by physical or acute emotional stress, that …
[HTML][HTML] Uptake-leak balance of SR Ca2+ determines arrhythmogenic potential of RyR2R420Q+/− cardiomyocytes
R Lopez, R Janicek, M Fernandez-Tenorio… - Journal of molecular and …, 2022 - Elsevier
Mutations of the RyR2 are channelopathies that can predispose to life threatening
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …