The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal
pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure …

Contraction of striated muscle is triggered by a massive release of calcium from the
sarcoplasmic reticulum (SR) into the cytoplasm. This intracellular calcium release is initiated …

Dysfunction of the sinoatrial node (SAN), the natural heart pacemaker, is common in heart
failure (HF) patients. SAN spontaneous activity relies on various ion currents in the plasma …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Andersen–Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of
unknown mechanism. In this study, we generated and characterized a mouse model of …

Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death
(SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic …

Key points In cardiac myocytes, subcellular local calcium release signals, calcium sparks,
are recruited to form each cellular calcium transient and activate the contractile machinery …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited cardiac arrhythmia condition, triggered by physical or acute emotional stress, that …

Mutations of the RyR2 are channelopathies that can predispose to life threatening
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …