Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …
A review of recent synthetic strategies and biological activities of isoxazole
CP Pandhurnekar, HC Pandhurnekar… - Journal of …, 2023 - Wiley Online Library
Among different heterocyclic compounds, isoxazole and their analogues are very important
classes of heterocyclic compounds as they display an extensive range of biological actions …
classes of heterocyclic compounds as they display an extensive range of biological actions …
Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation
Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
Isoxazole/Isoxazoline skeleton in the structural modification of natural products: a review
X Wang, Q Hu, H Tang, X Pan - Pharmaceuticals, 2023 - mdpi.com
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
Ultrasound-assisted transition-metal-free catalysis: a sustainable route towards the synthesis of bioactive heterocycles
B Borah, LR Chowhan - RSC advances, 2022 - pubs.rsc.org
Heterocycles of synthetic and natural origin are a well-established class of compounds
representing a broad range of organic molecules that constitute over 60% of drugs and …
representing a broad range of organic molecules that constitute over 60% of drugs and …
The potency of heterocyclic curcumin analogues: An evidence-based review
Curcumin, a potent phytochemical, has been a significant lead compound and has been
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies
Curcumin is an extensively studied natural compound due to its extensive biological
applications. However, there are some drawbacks linked to this compound such as poor …
applications. However, there are some drawbacks linked to this compound such as poor …
Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity …
MS El-Shoukrofy, HA Abd El Razik, OM AboulWafa… - Bioorganic …, 2019 - Elsevier
New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …
New pyrimidine-5-carbonitriles as COX-2 inhibitors: design, synthesis, anticancer screening, molecular docking, and in silico ADME profile studies
Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …