The hitchhiker's guide to flow chemistry∥
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …
stream rather than in a flask. Flow equipment provides chemists with unique control over …
[HTML][HTML] Automating drug discovery
G Schneider - Nature reviews drug discovery, 2018 - nature.com
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …
which various characteristics of compounds—including efficacy, pharmacokinetics and …
Flow chemistry: recent developments in the synthesis of pharmaceutical products
R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …
Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients
B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …
millimeter region have found widespread application in organic synthesis. The characteristic …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
Liquid phase oxidation chemistry in continuous-flow microreactors
HPL Gemoets, Y Su, M Shang, V Hessel… - Chemical Society …, 2016 - pubs.rsc.org
Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
A Buitrago Santanilla, EL Regalado, T Pereira… - Science, 2015 - science.org
At the forefront of new synthetic endeavors, such as drug discovery or natural product
synthesis, large quantities of material are rarely available and timelines are tight. A …
synthesis, large quantities of material are rarely available and timelines are tight. A …
Combining generative artificial intelligence and on-chip synthesis for de novo drug design
Automating the molecular design-make-test-analyze cycle accelerates hit and lead finding
for drug discovery. Using deep learning for molecular design and a microfluidics platform for …
for drug discovery. Using deep learning for molecular design and a microfluidics platform for …
Microfluidics for biomedical analysis
Y Yang, Y Chen, H Tang, N Zong, X Jiang - Small methods, 2020 - Wiley Online Library
Many new techniques and materials have been applied to microfluidic systems in the past
decade, and integrated microfluidic chips have become powerful platforms for realizing …
decade, and integrated microfluidic chips have become powerful platforms for realizing …
Quantum harmonic oscillator state synthesis by reservoir engineering
D Kienzler, HY Lo, B Keitch, L De Clercq, F Leupold… - Science, 2015 - science.org
The robust generation of quantum states in the presence of decoherence is a primary
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …