The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

[HTML][HTML] Automating drug discovery

G Schneider - Nature reviews drug discovery, 2018 - nature.com
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …

Flow chemistry: recent developments in the synthesis of pharmaceutical products

R Porta, M Benaglia, A Puglisi - Organic Process Research & …, 2016 - ACS Publications
Recently, application of the flow technologies for the preparation of fine chemicals, such as
natural products or Active Pharmaceutical Ingredients (APIs), has become very popular …

Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs

J Shelton, X Lu, JA Hollenbaugh, JH Cho… - Chemical …, 2016 - ACS Publications
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Liquid phase oxidation chemistry in continuous-flow microreactors

HPL Gemoets, Y Su, M Shang, V Hessel… - Chemical Society …, 2016 - pubs.rsc.org
Continuous-flow liquid phase oxidation chemistry in microreactors receives a lot of attention
as the reactor provides enhanced heat and mass transfer characteristics, safe use of …

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

A Buitrago Santanilla, EL Regalado, T Pereira… - Science, 2015 - science.org
At the forefront of new synthetic endeavors, such as drug discovery or natural product
synthesis, large quantities of material are rarely available and timelines are tight. A …

Combining generative artificial intelligence and on-chip synthesis for de novo drug design

F Grisoni, BJH Huisman, AL Button, M Moret, K Atz… - Science …, 2021 - science.org
Automating the molecular design-make-test-analyze cycle accelerates hit and lead finding
for drug discovery. Using deep learning for molecular design and a microfluidics platform for …

Microfluidics for biomedical analysis

Y Yang, Y Chen, H Tang, N Zong, X Jiang - Small methods, 2020 - Wiley Online Library
Many new techniques and materials have been applied to microfluidic systems in the past
decade, and integrated microfluidic chips have become powerful platforms for realizing …

Quantum harmonic oscillator state synthesis by reservoir engineering

D Kienzler, HY Lo, B Keitch, L De Clercq, F Leupold… - Science, 2015 - science.org
The robust generation of quantum states in the presence of decoherence is a primary
challenge for explorations of quantum mechanics at larger scales. Using the mechanical …