Efavirenz: history, development and future

B Costa, N Vale - Biomolecules, 2022 - mdpi.com
Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor
(NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the …

Global systematic review of common mental health disorders in adults living with HIV

J Hoare, T Sevenoaks, B Mtukushe, T Williams… - Current HIV/AIDS …, 2021 - Springer
Purpose of the review By reviewing the most recent common mental health disorders
(CMHD) studies in people living with HIV (PLWH)(2018-2020), this review discusses the …

COVID-19 and mental health of older Africans: an urgency for public health policy and response strategy

RM Gyasi - International Psychogeriatrics, 2020 - cambridge.org
The novel coronavirus disease 2019 (COVID-19) has emerged as a global public health
challenge and profoundly continues to inundate governments, economies, health systems …

Prevalence and factors associated with hyperglycemia among persons living with HIV/AIDS on dolutegravir-based antiretroviral therapy in Uganda

LH Byereta, R Olum, EI Mutebi… - Therapeutic …, 2024 - journals.sagepub.com
Background: Dolutegravir-based (DTG) regimens are rapidly becoming the preferred first-
line antiretroviral therapy (ART) for people living with HIV (PLHIV) in low and middle-income …

Gen Z and HIV—Strategies for Optimizing the Care of the Next Generation of Adolescents Living with HIV

I Dufour, Y Fougère, T Goetghebuer, M Hainaut… - Viruses, 2023 - mdpi.com
The management of adolescents living with HIV represents a particular challenge in the
global response to HIV. The challenges specific to this age group include difficulties …

Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer's Disease Therapeutics

B Boyarko, S Podvin, B Greenberg… - ACS Pharmacology & …, 2024 - ACS Publications
Therapeutic research and development for Alzheimer's disease (AD) has been an area of
intense research to alleviate memory loss and neurodegeneration. There is growing interest …

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

YT Tsai, SP KM, HC Ku, YL Wu, NY Ko - PloS one, 2023 - journals.plos.org
Death by suicide is a major public health problem. People living with human
immunodeficiency virus (PLHIV) have higher risk of suicidal behavior than the general …

Comparison of the accuracy of the 7-item HADS Depression subscale and 14-item total HADS for screening for major depression: A systematic review and individual …

Y Wu, B Levis, FM Daray, J Ioannidis… - Psychological …, 2023 - psycnet.apa.org
Abstract The seven-item Hospital Anxiety and Depression Scale Depression subscale
(HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major …

Oral Administration of Efavirenz Dysregulates the Tph2 Gene in Brain Serotonergic Areas and Alters Weight and Mood in Mice

SA Rojas-Osornio, M Crespo-Ramírez… - Pharmaceuticals, 2024 - mdpi.com
Most HIV-antiretroviral drugs have adverse effects. Efavirenz (EFV) is an example of a drug
with neuropsychiatric effects, such as anxiety, depression, and suicidal thoughts, in people …

[HTML][HTML] High Prevalence of Severe Depression in Mexican Patients Diagnosed with HIV Treated with Efavirenz and Atazanavir: Clinical Follow-Up at Four Weeks and …

SA Rojas-Osornio, F Guerra-Castillo… - Journal of Clinical …, 2024 - mdpi.com
Efavirenz (EFV) causes neuropsychiatric effects such as anxiety, depression, and suicidal
thoughts in people with HIV (PWH). Depressive disorders have been associated with the …