As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Exposure of blood to a foreign surface in the form of a diagnostic or therapeutic biomaterial
device or implanted cells or tissue elicits an immediate, evolutionarily conserved …

Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an
inflammatory response pathway with diverse vascular permeability functions, including …

Introduction: Blood coagulation factor XII (FXII) is an emerging and potentially safe drug
target, which dysregulation is associated with thrombosis, hereditary angioedema, and …

Patients with hereditary angioedema (HAE) experience episodes of bradykinin (BK)-induced
swelling of skin and mucosal membranes. The most common cause is reduced plasma …

Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of
soft tissue swelling due to excessive bradykinin production. In most cases, dysregulation of …

In the modern world, complications caused by disorders in the blood coagulation system are
found in almost all areas of medicine. Thus, the development of new, more advanced drugs …

Biomedical devices are prone to blood clot formation (thrombosis), and liquid‐infused
surfaces (LIS) are effective in reducing the thrombotic response. However, the mechanisms …

We herein report the conventional and microscale parallel synthesis of selective inhibitors of
human blood coagulation factor XIIa and thrombin exhibiting a 1, 2, 4-triazol-5-amine …

Some coumarin derivatives show notable anticoagulant properties through their ability to
interrupt the enzymatic function of vitamin K epoxide reductase. The current challenge lies in …