Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

While correlations between drug-induced cortisol elevation, self-reported anxiety, and
treatment outcomes have been reported for human studies during psilocybin-assisted …

Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First
generation or typical antipsychotics such as haloperidol and second generation or atypical …

The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder
(AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in …

Until the last quarter of the 20th century, sex was not recognized as a variable in health
research, nor was it believed to be a factor that could affect health and illness. Researchers …

Rationale Serotonergic psychedelics exert their effects via their high affinity for serotonin (5-
HT) receptors, particularly through activating 5-HT2A receptors (5-HT2AR), employing the …

Recent evidence indicates that neuronal activity within the claustrum (CLA) may be central
to cellular and behavioral responses to psychedelic hallucinogens. The CLA prominently …

There is increasing interest in the therapeutic potential of psilocybin. In rodents, the
serotonin precursor, 5-hydroxytryptophan (5-HTP) and psilocybin induce a characteristic 5 …

Emerging evidence suggests that classical psychedelics possess immunomodulatory and
anti-inflammatory properties; however, these effects are yet to be well-established. This …