The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

The rapid growth of obesity worldwide has made it a major health problem, while the
dramatic increase in the prevalence of obesity has had a significant impact on the …

Based on available data, adiponectin represents a multifaceted biomarker that may
beneficially affect atherosclerosis, inflammation and insulin resistance pathways. However …

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …

Organ-on-a-chip systems possess a promising future as drug screening assays and as
testbeds for disease modeling in the context of both single-organ systems and multi-organ …

Diabetic kidney disease (DKD) is a major complication for diabetic patients. Adiponectin is
an insulin sensitizer and anti-inflammatory adipokine and is mainly secreted by adipocytes …

Adiponectin is the adipokine associated with insulin sensitization, reducing liver
gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is …

Chronic kidney disease is among the fastest growing causes of death worldwide. An
increased risk of all-cause and cardiovascular death is thought to depend on the …

There is extensive evidence showing that insulin resistance (IR) is associated with chronic
low-grade inflammation. Furthermore, IR has been shown to increase the risk for …

The rapid growth in obesity worldwide contributes to an increase in metabolic syndrome and
obesity-related kidney disease with an enhanced increased risk for chronic kidney disease …