The global decline in malaria has stalled, emphasizing the need for vaccines that induce
durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination …

The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein
homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease …

Introduction: An effective vaccine against malaria forms a global health priority. Both
naturally acquired immunity and sterile protection induced by irradiated sporozoite …

Pre-existing and intervening low-density Plasmodium infections complicate the conduct of
malaria clinical trials. These infections confound infection detection endpoints, and their …

Background Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal,
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …

Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with
antimalarial drugs (PfSPZ-CVac), confers superior sterilizing protection against infection …

New therapeutics are necessary for preventing Plasmodium vivax malaria due to easy
transmissibility and dormancy in the liver that increases the clinical burden due to recurrent …

Whole-sporozoite vaccines engender sterilizing immunity against malaria in animal models
and importantly, in humans. Gene editing allows for the removal of specific parasite genes …

BACKGROUND Naturally acquired immunity to malaria is incompletely understood. We
used controlled human malaria infection (CHMI) to study the impact of past exposure on …

Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …