Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence
X Bai, T Schountz, AM Buckle, JL Talbert… - Biochemical Society …, 2023 - portlandpress.com
Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to
inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID …
inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID …
Cell-based therapy for the treatment of glioblastoma: an update from preclinical to clinical studies
Glioblastoma (GB), an aggressive primary tumor of the central nervous system, represents
about 60% of all adult primary brain tumors. It is notorious for its extremely low (~ 5%) 5-year …
about 60% of all adult primary brain tumors. It is notorious for its extremely low (~ 5%) 5-year …
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
K Sivaraman, S Wrenger, B Liu… - Journal of leukocyte …, 2023 - academic.oup.com
Rodent models of lipopolysaccharide (LPS)–induced pulmonary inflammation are used for
anti-inflammatory drug testing. We aimed to characterize mice responses to aerosolized LPS …
anti-inflammatory drug testing. We aimed to characterize mice responses to aerosolized LPS …
Análisis de la expresión del gen SERPINA1 en la infección por SARS-CoV-2: estudio de un nuevo biomarcador
M Pintanel-Raymundo, S Menao-Guillén… - Revista Clínica …, 2024 - Elsevier
Introducción El gen SERPINA1 codifica la proteína alfa-1 antitripsina (AAT1). Los posibles
desequilibrios entre las concentraciones de proteasas y antiproteasas (AAT1) puede hacer …
desequilibrios entre las concentraciones de proteasas y antiproteasas (AAT1) puede hacer …
Analysis of the expression of the Serpina1 gene in SARS-CoV-2 infection: study of a new biomarker
M Pintanel-Raymundo, S Menao-Guillén… - Revista Clínica …, 2024 - Elsevier
Introduction The SERPINA1 gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible
imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to …
imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to …
d‐Galactose treatment increases ACE2, TMPRSS2, and FURIN and reduces SERPINA1 mRNA expression in A549 human lung epithelial cells
G Baristaite, D Gurwitz - Drug Development Research, 2022 - Wiley Online Library
Several comorbidities including diabetes, immune deficiency, and chronic respiratory
disorders increase the risk of severe Covid‐19 and fatalities among SARS‐CoV‐2 infected …
disorders increase the risk of severe Covid‐19 and fatalities among SARS‐CoV‐2 infected …