Challenges and toxicity assessment of inorganic nanomaterials in biomedical applications: Current status and future roadmaps

P Mahamuni-Badiger, MJ Dhanavade - Journal of Drug Delivery Science …, 2023 - Elsevier
Nano-world is expanding rapidly due to the amalgamation of different science disciplines.
Nanomaterials (NMs) have wide applications in the biomedical field due to their unique …

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

L Varisli, O Cen, S Vlahopoulos - Immunology, 2020 - Wiley Online Library
Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …

Fabrication of chitosan/PVP/dihydroquercetin nanocomposite film for in vitro and in vivo evaluation of wound healing

J Zhang, K Chen, C Ding, S Sun, Y Zheng… - International Journal of …, 2022 - Elsevier
The high cost of wound healing treatment, the slow recovery of wounds, and the uncertainty
of being affected by the body's physiological activities constitute a serious burden on public …

Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways

Z Du, Z Ma, S Lai, Q Ding, Z Hu, W Yang… - Frontiers in …, 2022 - frontiersin.org
Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen
species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide …

Lysosome-targeted fluorescence probe for discriminating cysteine from homocysteine/glutathione and assessing autophagy in drug-induced liver injury

J Zeng, T Yang, M Liu, S Li, D Cheng, L He - Sensors and Actuators B …, 2023 - Elsevier
Autophagy inhibition is an early cause of drug-induced liver injury (DILI). Cysteine (Cys)
levels in lysosomes are associated with autophagy. Detecting Cys in lysosomes visually is a …

Hepatoprotective effect of rhein against methotrexate-induced liver toxicity

T Bu, C Wang, Q Meng, X Huo, H Sun, P Sun… - European journal of …, 2018 - Elsevier
The purpose of this study was to investigate the protective effect of rhein, a major metabolite
of diacerein, on methotrexate (MTX)-induced hepatotoxicity and clarify the pharmacological …

[HTML][HTML] Dihydroquercetin composite nanofibrous membrane prevents uva radiation-mediated inflammation, apoptosis and oxidative stress by modulating mapks/nrf2 …

J Zhang, Y Zheng, B Hong, L Ma, Y Zhao… - Biomedicine & …, 2022 - Elsevier
Exposure to ultraviolet (UV) radiation is a key cause of skin inflammation and photodamage
in the environment. Dihydroquercetin composite nanofiber membrane (CPD) is a nano-scale …

Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat‐induced skeletal muscle injury

T Yu, J Dohl, Y Chen, HG Gasier… - Journal of Cellular …, 2019 - Wiley Online Library
Heat stress causes mitochondrial dysfunction and increases mitochondrial production of
reactive oxygen species (ROS), both of which contribute to heat‐induced skeletal muscle …

FTY720 attenuates APAP‑induced liver injury via the JAK2/STAT3 signaling pathway

X He, K Kang, D Pan, Y Sun… - … Journal of Molecular …, 2022 - spandidos-publications.com
As the current clinical treatment of acetaminophen (APAP)‑induced liver injury (AILI) has its
limitations, new and effective treatment methods are required. Fingolimod (FTY720) is an …

Autophagy plays a double-edged sword role in liver diseases

J Zhou, J Wang, H Ren, X Shi - Journal of physiology and biochemistry, 2022 - Springer
As a highly evolutionarily conserved process, autophagy can be found in all types of
eukaryotic cells. Such a constitutive process maintains cellular homeostasis in a wide variety …