Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib

F Ran, Y Liu, C Wang, Z Xu, Y Zhang, Y Liu… - European Journal of …, 2022 - Elsevier
Bruton's tyrosine kinase (BTK) regulates multiple important signaling pathways and plays a
key role in the proliferation, survival, and differentiation of B-lineage cells and myeloid cells …

Biological drugs for the treatment of children with chronic spontaneous urticaria

I Podder, A Salman, R Asero… - Expert Review of …, 2024 - Taylor & Francis
Introduction There is a significant prevalence of chronic spontaneous urticaria (CSU) in
children across the globe. Some children with CSU do not achieve disease control with first …

[HTML][HTML] Guardians of Immunity: Advances in Primary Immunodeficiency Disorders and Management

NC Peddi, S Vuppalapati, H Sreenivasulu… - Cureus, 2023 - ncbi.nlm.nih.gov
Primary immunodeficiency disorders (PIDs) are a heterogeneous group of genetic
conditions profoundly impacting immune function. The investigation spans various PID …

[HTML][HTML] Knockout of Bruton's tyrosine kinase in macrophages attenuates diabetic nephropathy in streptozotocin-induced mice

Z Fan, Y Li, L Xia, Y Wu - American Journal of Translational …, 2021 - ncbi.nlm.nih.gov
As a cytoplasmic tyrosine kinase in the Tec family, Bruton's tyrosine kinase (Btk) participates
in various biological processes, including cell growth, differentiation, and apoptosis …

Impacto de la determinación de subpoblaciones linfocitarias en el pronóstico y respuesta al tratamiento en pacientes con inmunodeficiencias primarias

LAB Velasco, ÁPM Veloz - Conocimiento global, 2024 - conocimientoglobal.org
Las enfermedades de inmunodeficiencia primaria (IDP) forma parte de un gran conjunto de
alrededor de 400 trastornos con defectos o alteraciones en las funciones y/o desarrollo de …