Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …

Background Wilms tumour is the most common childhood renal cancer and is genetically
heterogeneous. While several Wilms tumour predisposition genes have been identified …

Autophagy plays a pivotal role in physiology and pathophysiology, including cancer.
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Simple Summary A Wilms tumor is a childhood kidney tumor. In high-income countries, 90%
of patients with this tumor survive. However, the tumor recurs in 15% of patients. It is …

Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of
which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer …