Chronic, low-grade inflammation, or inflammaging, is a crucial contributor to various age-
related pathologies and natural processes in aging tissue, including the nervous system …

Inflammation is a complex biological response to harmful stimuli including infection, tissue
damage, and toxins. Thus, it is not surprising that cochlear damage by noise includes an …

The inner ear, like all organs, interacts with the systemic immune system via lymphatic
drainage and vascular circulation to protect itself from infections and stress such as acoustic …

Owing to their proximity to areas exposed to infection, the sensory organs of the inner ear
are probably dependent on an efficient antimicrobial defence. The longitudinal flow of …

The inner ear is capable of rapidly mounting an immune response that can ultimately lead to
cochlear degeneration and permanent hearing loss. The role of the endolymphatic sac in …

The percentage of macrophage subpopulations based on their origins in the adult cochlea
remains unclear. This study aimed to elucidate the origins of cochlear macrophages during …

Background: The endolymphatic sac (ES) is endowed with a multitude of white blood cells
that may trap and process antigens that reach the inner ear from nearby infection-prone …

In healthy human temporal bones, immunoglobulins (IgG, IgA) and the secretory component
are demonstrated by two immunohistochemical methods in epithelial cells and in the lumen …

The slow accumulation of inflammatory biomarker levels in the body—also known as
inflammaging—has been linked to a myriad of age-related diseases. Some of these include …

Abstract Adeno-associated virus (AAV)-mediated inner ear gene therapy is a promising
treatment option for hearing loss and dizziness. Several studies have shown that AAV …