Recent developments in chimeric NSAIDs as safer anti‐inflammatory agents
NSAIDs are among the most widely prescribed medications across the world, but the
gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current …
gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current …
Chemical modifications of ketoprofen (NSAID) in search of better lead compounds: A Review of literature from 2004-2016
Background: Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug
belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple …
belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple …
Design, synthesis and in vitro antimicrobial activity of novel phenylbenzamido-aminothiazole-based azasterol mimics
RK Yadlapalli, OP Chourasia, MP Jogi… - Medicinal Chemistry …, 2013 - Springer
Phenylbenzamide framework as a mimic of the azasterol structure was investigated by
synthesizing 4-phenylbenzamido-2-aminothiazole 4, and evaluating its MIC against …
synthesizing 4-phenylbenzamido-2-aminothiazole 4, and evaluating its MIC against …
Insights into Prospects of Novel NSAID Prodrugs in the Management of Gastrointestinal Toxicity: A Perspective Review
Non-steroidal anti-inflammatory drugs (NSAIDs) have a long history in the healthcare system
due to their therapeutic potential. These NSAIDs cause ulcerogenicity, stomach pains …
due to their therapeutic potential. These NSAIDs cause ulcerogenicity, stomach pains …
1, 2, 4-Oxadiazole Incorporated Ketoprofen Analogues in Search of Safer Non-steroidal Anti-inflammatory Agents: Design, Syntheses, Biological Evaluation and …
Background: Improving the gastrointestinal safety profile of Non-Steroidal Anti-Inflammatory
Drugs (NSAIDs) is an important goal. An important strategy to develop NSAIDs with minimal …
Drugs (NSAIDs) is an important goal. An important strategy to develop NSAIDs with minimal …
[PDF][PDF] Design and synthesis of n-substituted aminothiazole compounds as anti-inflammatory agents
A Fatima, R Kulkarni, B Mantipragada - Der Pharma Chemica, 2015 - academia.edu
ABSTRACT A series of new N-(4-phenyl-1, 3-thiazol-2-yl) benzamides (5a-o) has been
synthesized from 2-amino-4-substituted phenylthiazoles and substituted benzoyl chlorides …
synthesized from 2-amino-4-substituted phenylthiazoles and substituted benzoyl chlorides …
Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
S Naz, FA Shah, H Nadeem, S Sarwar… - Drug Design …, 2021 - Taylor & Francis
Purpose The development of resistance to available anticancer drugs is increasingly
becoming a major challenge and new chemical entities could be unveiled to compensate …
becoming a major challenge and new chemical entities could be unveiled to compensate …
[HTML][HTML] Synthesis and biological evaluation of a mutual prodrug of norfloxacin and fenbufen
Objectives The study aimed to synthesize a mutual prodrug of norfloxacin and fenbufen with
an objective of obtaining an effective and safer anti-inflammatory drug with useful …
an objective of obtaining an effective and safer anti-inflammatory drug with useful …
[PDF][PDF] Synthesis of new conjugates of some NSAIDs with sulfonamide as possible mutual prodrugs using tyrosine spacer for colon targeted drug delivery
SL Abdulhadi, AJ Qasir, NAA Razzak - … Sciences (P-ISSN: 1683-3597, E …, 2013 - iasj.net
The purpose of this research work is to synthesize conjugates of some NSAIDs with
sulfamethoxazole as possible mutual prodrugs to overcome the local gastric irritation of …
sulfamethoxazole as possible mutual prodrugs to overcome the local gastric irritation of …
NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
S Jain - 2012 - era.library.ualberta.ca
The objective of this work was to synthesize and evaluate the biological properties of a new
series of nitric oxide-releasing non-steroidal antiinflammatory drugs (NO-NSAIDs) …
series of nitric oxide-releasing non-steroidal antiinflammatory drugs (NO-NSAIDs) …