The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Cannabidiol for neurodegenerative disorders: A comprehensive review

S Bhunia, N Kolishetti, AY Arias, A Vashist… - Frontiers in …, 2022 - frontiersin.org
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

Cannabinoid formulations and delivery systems: Current and future options to treat pain

B Stella, F Baratta, C Della Pepa, S Arpicco, D Gastaldi… - Drugs, 2021 - Springer
The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in
recent decades and a growing body of evidence suggests that phytocannabinoids are …

[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines

A Pérez-López, AI Torres-Suárez… - Advanced Drug Delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

[HTML][HTML] Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment

P Graván, A Aguilera-Garrido, JA Marchal… - Advances in Colloid and …, 2023 - Elsevier
Nanotechnological drug delivery platforms represent a new paradigm for cancer
therapeutics as they improve the pharmacokinetic profile and distribution of …

The endocannabinoid system: A target for cancer treatment

C Laezza, C Pagano, G Navarra, O Pastorino… - International journal of …, 2020 - mdpi.com
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …

Cannabinoids, blood–brain barrier, and brain disposition

F Calapai, L Cardia, EE Sorbara, M Navarra… - Pharmaceutics, 2020 - mdpi.com
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory …

Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

SK Jha, VK Nelson, PR Suryadevara, SP Panda… - Ageing Research …, 2024 - Elsevier
Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …

Current challenges and opportunities for improved cannabidiol solubility

KR Hossain, A Alghalayini, SM Valenzuela - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to
its potential therapeutic benefits. However, one of the challenges associated with CBD …

[HTML][HTML] Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literature

S Pagano, M Coniglio, C Valenti, MI Federici… - Biomedicine & …, 2020 - Elsevier
A systematic review was performed to evaluate the biological effects of Cannabidiol (CBD),
one of the major components of Cannabis Sativa, on normal human healthy cell populations …