Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer
protection against oxidant stress. The development of hypertension, muscle/neuro‑​ …

Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Plants of the genus Terminalia are amongst the most widely used plants for traditional
medicinal purposes worldwide. Many species are used for their antibacterial, antifungal …

Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione
(GSH) precursor N‐acetylcysteine (NAC) is used to treat patients with APAP overdose for up …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …