The heart holds the monumental yet monotonous task of maintaining circulation. Although
cardiac function is critical to other organs and to life itself, mammals are not equipped with …

Role of Cardiac Stem Cells in Cardiac Pathophysiology: A Paradigm Shift in Human Myocardial
Biology Page 1 Review This Review is part of a thematic series on Stem Cells, which includes …

Microfabrication technology provides a highly versatile platform for engineering hydrogels
used in biomedical applications with high-resolution control and injectability. Herein, we …

Mesenchymal stem cells (MSCs) have been used for cell therapy in various experimental
disease models. However, the regenerative potential of MSCs from different tissue sources …

Controversy surrounds the identity, origin, and physiologic role of endogenous
cardiomyocyte progenitors in adult mammals. Using an inducible genetic labeling approach …

The adult mammalian heart was once believed to be a post-mitotic organ without any
capacity for regeneration, but recent findings have challenged this dogma. A modified view …

Over the past decade, extensive work in animal models and humans has identified the
presence of adult cardiac progenitor cells, capable of cardiomyogenic differentiation and …

The heart's limited regenerative capacity raises the need for novel stem cell-based
therapeutic approaches for cardiac regeneration. However, the use of stem cells is restrictive …

Aims Several cardiac resident progenitor cell types have been reported for the adult
mammalian heart. Here we characterize their frequencies and distribution pattern in non …

Background A major hurdle in the use of exogenous stems cells for therapeutic regeneration
of injured myocardium remains the poor survival of implanted cells. To date, the delivery of …