Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a
thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and …

The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑
CoV‑2) focused many researchers attention to find treatments that can suppress …

Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from
the critical illness itself, and results in sustained disability long after the ICU stay. Weakness …

In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Cancer formation is a highly regulated and complex process, largely dependent on its
microenvironment. This complexity highlights the need for developing novel target-based …

Autophagy is a highly conserved metabolic process involved in the degradation of
intracellular components including proteins and organelles. Consequently, it plays a critical …

Background Glioblastoma multiforme (GBM) is the most common and aggressive brain
tumor. Metformin, an anti-diabetic drug, can suppress tumor cells. Exosomes from GBM cells …

Cancer resistance to anti-tumour agents has been one of the serious challenges in different
types of cancer treatment. Usually, an increase in the cell death markers can predict a higher …