[HTML][HTML] The mechanism of HMGB1 secretion and release
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …
[HTML][HTML] Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
TGF-β: the master regulator of fibrosis
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
[HTML][HTML] METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy
L Jiang, X Liu, X Hu, L Gao, H Zeng, X Wang, Y Huang… - Molecular Therapy, 2022 - cell.com
Epigenetic changes are present in many physiological and pathological processes. The N 6-
methyladenosine (m6A) modification is the most common modification in eukaryotic mRNA …
methyladenosine (m6A) modification is the most common modification in eukaryotic mRNA …
[HTML][HTML] Molecular mechanisms of diabetic kidney disease
K Reidy, HM Kang, T Hostetter… - The Journal of clinical …, 2014 - Am Soc Clin Investig
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …
[HTML][HTML] Podocyte injury and its consequences
M Nagata - Kidney international, 2016 - Elsevier
Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …
on their highly differentiated postmitotic phenotype, which also defines the particular …
Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog
M Edeling, G Ragi, S Huang, H Pavenstädt… - Nature Reviews …, 2016 - nature.com
Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …
[HTML][HTML] Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
M Liu, K Liang, J Zhen, M Zhou, X Wang… - Nature …, 2017 - nature.com
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …
Glomerular mesangial cell and podocyte injuries in diabetic nephropathy
CW Tung, YC Hsu, YH Shih, PJ Chang, CL Lin - Nephrology, 2018 - Wiley Online Library
Diabetic nephropathy is one of the leading causes of end‐stage renal disease and creates
heavy healthcare burdens globally. Dysfunction of mesangial cells and podocytes …
heavy healthcare burdens globally. Dysfunction of mesangial cells and podocytes …